Sequential Ugi Four‐Component Reaction (4‐CR)/CH Activation Using (Diacetoxyiodo)benzene for the Synthesis of 3‐(Diphenylmethylidene)‐2,3‐dihydro‐1H‐indol‐2‐ones |
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| Authors: | Elmira Ghabraie Saeed Balalaie |
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| Institution: | 1. Peptide Chemistry Research Center, K.?N. Toosi University of Technology, P.O. Box 15875‐4416 Tehran, Iran (fax: +98‐21‐2285?3650);2. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran |
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| Abstract: | A sequential Ugi four‐component reaction (4‐CR)/C? H activation using (diacetoxyiodo)benzene is reported. This process is a five‐component reaction of aromatic aldehydes, aniline derivatives, isocyanides, phenylpropiolic acid (3‐phenylprop‐2‐ynoic acid), and (diacetoxyiodo)benzene for the synthesis of 3‐(diphenylmethylidene)‐2,3‐dihydro‐1H‐indol‐2‐ones. This procedure offers several advantages such as good yields, high bond‐forming efficiency, selectivity, and short reaction times. |
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| Keywords: | (Diacetoxyiodo)benzene Sequential Ugi four‐component reaction/C H activation 1H‐Indol‐2‐ones 3‐(diphenylmethylidene)‐2 3‐dihydro‐ C H Activation Five‐component reaction Palladium catalysis |
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