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Ethenolate Transfer Reactions: A Facile Synthesis of Vinyl Esters |
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| Authors: | Srinivasan Kaliyaperumal?Appaye Satish Pandurang?Nikumbh Rajeshwar Reddy?Govindapur Shyamapada Banerjee Dinesh S Bhalerao Unniaran K Syam Kumar |
| Institution: | 1. Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad, Pin 500 049, India;2. Chemistry Division, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Pin 500 072, India;3. Integrated Product Development, Innovation Plaza, Dr. Reddy's Laboratories Ltd., Bachupalli, Qutubullapur, R.?R. Dist. 500 072, Andhra Pradesh, India |
| Abstract: | A simple and efficient metal‐free ethenolate transfer reaction has been elaborated in moderate‐to‐high yields from vinyl acetate. This reaction was accomplished by generation of potassium ethenolate, which was then reacted with homo and mixed anhydrides of aliphatic, aryl and heteroaryl acids, to yield the corresponding vinyl esters. The utility of thus generated vinyl esters was then probed by carrying out intramolecular Heck reactions to give isobenzofuran‐1(3H)‐one derivatives in excellent yields. |
| Keywords: | Acetates vinyl Anhydrides mixed Ethenolates vinyl Heck reaction Isobenzofuran‐1(3H)‐ones |