A New Polyketide from the Mangrove Endophytic Fungus Penicillium sp. sk14JW2P |
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| Authors: | Xi‐Shan Huang Bin Yang Xue‐Feng Sun Guo‐Ping Xia Ya‐Yue Liu Lin Ma Zhi‐Gang She |
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| Affiliation: | School of Chemistry and Chemical Engineering, Sun Yat‐sen University, #135, Xingang West Road, Haizhu District, Guangzhou 510275, P.?R. China, (phone: +86‐20‐84113356) |
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| Abstract: | Two polyketides were isolated from the mangrove endophytic fungus, Penicillium sp. sk14JW2P, and one derivative with a modified structure. The structures were elucidated by spectroscopic analyses, the structure of the compound 1 was further confirmed by single‐crystal X‐ray diffraction, and its absolute configuration was determined. Compound 1 and 2 showed acetylcholinesterase (AchE) inhibitory activities with IC50 values of 12±0.3 and 79±2 nM , respectively. |
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| Keywords: | Penicillium Fungi Polyketides Palitantin Acetylcholinesterase (AchE) inhibitory activity X‐Ray crystallography |
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