Two New Cycloartane Triterpenoids from Kleinhovia hospita |
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| Authors: | Jian‐Xia Mo Yang Bai Bo Liu Chang‐Xin Zhou Li Zou Li‐She Gan |
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| Institution: | 1. Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.?R. China (phone: +86‐571‐88208457;2. fax: +86‐571‐88208445);3. College of Information Science & Technology, Hainan University, Haikou 570228, P.?R. China;4. Guangdong Provincial Academy of Chinese Medical Sciences (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), 55 Neihuanxi Road, Guangzhou 510006, P.?R. China |
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| Abstract: | Two new cycloartane triterpenoids, (23R)‐21,23:23,27‐diepoxycycloarta‐1,24‐diene‐3,27‐dione ( 1 ) and (3α)‐(α‐L ‐arabinopyranosyloxy)‐1α‐hydroxy‐23‐oxocycloartan‐28‐oic acid ( 2 ), together with six known pentacyclic triterpenoids, 3 – 8 , and five known C29 steroids, 9 – 13 , were isolated from Kleinhovia hospita. The structures of these compounds were determined by analysis of their spectroscopic data. Moreover, the absolute configuration of 1 was confirmed by quantum‐chemical TDDFT calculation of its ECD spectrum. All compounds were evaluated for their cytotoxic activities against human colon carcinoma (HCT116) and gastric carcinoma (SGC7901) cell lines, and compounds 6, 7, 8, 11 , and 12 exhibited antiproliferative activities with IC50 values ranging from 23.0 to 91.8 μM . |
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| Keywords: | Kleinhovia hospita Terpenoids Cycloartane triterpenoids Cytotoxic activity Antiproliferative activity |
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