Prenylated Indole Alkaloid Derivatives from Marine Sediment‐Derived Fungus Penicillium paneum SD‐44 |
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| Authors: | Chun‐Shun Li Xiao‐Ming Li Chun‐Yan An Bin‐Gui Wang |
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| Institution: | 1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, P.?R. China, (phone: +86‐532‐82898553;2. fax: +86‐532‐82880645) |
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| Abstract: | Three new prenylated indole alkaloids, including two β‐carbolines, penipalines A and B ( 1 and 2 , resp.), and one indole carbaldehyde derivative, penipaline C ( 3 ), as well as two known indole derived analogs, 4 and 5 , were isolated from the deep‐sea‐sediment derived fungus Penicillium paneum SD‐44 cultured in a 500‐l bioreactor. The structures of the new compounds were determined on the basis of 1D‐ and 2D‐NMR spectroscopy, as well as by high‐resolution mass spectrometry. The new compounds 2 and 3 showed potent cytotoxic activities against A‐549 and HCT‐116 cell lines. |
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| Keywords: | Penicillium paneum β ‐Carbolines Alkaloids Indole alkaloids |
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