Coumarinolignans Isolated from the Seeds of Brucea javanica |
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| Authors: | Jianhong Yang Wenyu Liu Shucai Li Haoyu Ye Huan Tang Lijuan Chen Aihua Peng |
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| Institution: | 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.?R. China, (phone: +86?28?85164063;2. fax: +86?28?85164060) |
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| Abstract: | A new coumarinolignan, cleomiscosin E ( 1 ), together with the known compound cleomiscosin A ( 2 ), has been isolated from the seeds of Brucea javanica (L.) Merr . Their structures were assigned on the basis of spectral studies. These two compounds exhibited potent anti‐inflammatory activities by inhibiting the nitric oxide (NO) production in lipopolysaccharide (LPS)‐activated RAW264.7 macrophages. |
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| Keywords: | Cleomiscosins A and E Coumarinolignans Lignans Anti‐inflammatory activity |
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