Further Diterpenes from the Seeds of Caesalpinia minax Hance |
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| Authors: | Guo‐Xu Ma Hai‐Feng Wu Jing‐Quan Yuan Hua Wei Shuo Wang Xiao‐Po Zhang Yu Tian Jun‐Shan Yang Xu‐Dong Xu |
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| Institution: | 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, P.?R. China, (phone: +86‐10‐57833296;2. fax: +86‐10‐57833296);3. National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, National Development and Reform Commission, Guangxi Botanical Garden of Medicinal Plant, Nanning 530023, P.?R. China;4. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P.?R. China |
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| Abstract: | Three new cassane‐type diterpenes, neocaesalpin AF ( 1 ), neocaesalpin AG ( 2 ), and neocaesalpin AH ( 3 ), were isolated from the seeds of Caesalpinia minax Hance . Their structures were elucidated on the basis of extensive spectroscopic analyses. The partially hydrogenated lactone unit in a tetracyclic cassane diterpene in 2 is rarely encountered in the cassane diterpenes isolated from the genus Caesalpinia. All compounds were evaluated for their in vitro cytotoxic activities against HCT‐8 and MCF‐7 human cancer cell lines. |
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| Keywords: | Caesalpinia Cytotoxic activity Diterpenes Cassane |
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