Three New Phthalides from Gnaphalium adnatum |
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| Authors: | Xing‐Ping Zheng Qiong‐Fang Cui Jing‐Feng Zhao Li‐Juan Yang Hong‐Bin Zhang Xiao‐Dong Yang Liang Li |
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| Institution: | 1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.?R. China, (phone/fax: +86‐871‐65035538);2. Mengla Entry‐Exit Inspection and Quarantine Bureau, Mengla 666300, P.?R. China;3. Yuxi Agricultural Product Quality and Safety Inspection Testing Center, Yuxi 653100, P.?R. China;4. Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650500, P.?R. China |
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| Abstract: | Three new phthalides, gnaphalides A–C ( 1 – 3 , resp.), together with three known phthalides, were isolated from the aerial part of Gnaphalium adnatum. The structures of the new compounds were elucidated as 6‐(1,1‐dimethylprop‐2‐en‐1‐yl)‐5,7‐dihydroxy‐2‐benzofuran‐1(3H)‐one ( 1 ), 5‐hydroxy‐7‐(2‐hydroxy‐3‐methylbut‐3‐en‐1‐yl)oxy]‐2‐benzofuran‐1(3H)‐one ( 2 ), and 1,3‐dihydro‐7‐(3‐methylbut‐2‐en‐1‐yl)oxy]‐1‐oxo‐2‐benzofuran‐5‐yl β‐D ‐glucopyranoside ( 3 ) on the basis of spectral analyses. The structure of 1 was also confirmed by X‐ray crystallographic analysis. The three known phthalides, identified as 5,7‐dihydroxyisobenzofuran‐1(3H)‐one ( 4 ), anaphatol ( 5 ), and 7‐O‐(β‐glucopyranosyl)‐5‐hydroxyisobenzofuran‐1(3H)‐one ( 6 ), were isolated from the genus Gnaphalium for the first time. |
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| Keywords: | Phthalides Gnaphalides A – C Gnaphalium adnatum |
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