Two Novel Abietane Diterpenoids from Illicium wardii A.C.Sm. |
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| Authors: | Yan‐Ping Gao Yun‐Heng Shen Wei‐Dong Zhang |
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| Affiliation: | 1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, P.?R. China (phone/fax: +86‐21‐81871244);2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.?R. China (phone/fax:+86‐21‐81871245) |
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| Abstract: | Two novel abietane diterpenoids, wardinols A and B ( 1 and 2 , resp.), together with five known diterpenoids, 3 – 7 , were isolated from the fruits of Illicium wardii A.C.Sm . Their structures were elucidated on the basis of intensive spectroscopic analysis, including 1D‐ and 2D‐NMR spectroscopy. Wardinol A ( 1 ) is a rare 9,10‐epoxy‐9,10‐secoabietane diterpenoid. All of the isolated compounds were evaluated for their cytotoxicities against three human tumor cell lines, A549, HCT116, and CCRF‐CEM. |
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| Keywords: | Illicium wardii Abietane Diterpenoids Wardinols A and B Cytotoxic activity |
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