An Efficient Approach to the Synthesis of Hydrazinyl Pseudo‐Peptides |
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| Authors: | Vaezeh Fathi Sorour Ramezanpour Saeed Balalaie Frank Rominger Hamid Reza?Bijanzadeh |
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| Institution: | 1. Peptide Chemistry Research Center, K.?N. Toosi University of Technology, P.O. Box 15875‐4416, Tehran, Iran (fax: +98‐21‐22853650);2. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Organisch‐Chemisches Institut der Universit?t Heidelberg, ImNeuenheimer Feld 270, DE‐69120 Heidelberg |
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| Abstract: | New hydrazinyl pseudo‐peptides have been obtained from Ugi four‐component reaction (4CR). The 5‐hydrazinyl‐5‐oxopentanoic acids used as starting materials were prepared by the reaction of hydrazides with anhydrides. Mild reaction conditions, high atom economy, bond‐forming efficiency, and easy workup are advantages of this approach. The products have four amide bonds and high potential for H‐bonding. |
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| Keywords: | Ugi four‐component reaction Amide bond formation Multicomponent reactions |
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