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A Stereoselective Total Synthesis of Decarestrictine I |
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| Authors: | Jhillu Singh Yadav Miriyal Venkatesh Alleni Suman Kumar Poli Adi Narayana Reddy Basi V Subba Reddy Attaluri R Prasad |
| Institution: | Pheromone Group, CSIR‐Indian Institute of Chemical Technology, Hyderabad, 500607, India, (fax: 91‐40‐27160387) |
| Abstract: | A convergent and stereoselective total synthesis of decarestrictine I, a polyketide natural product, is described. Both acid and alcohol fragments were prepared from the readily available L ‐malic acid via Still? Gennari olefination and Sharpless asymmetric epoxidation. The Steglich esterification and ring‐closing metathesis (RCM) are employed to combine both acid and alcohol fragments. |
| Keywords: | Decanolides Decarestrictine I Still Gennari olefination Steglich esterification Ring closing metathesis (RCM) |