Detection of benzopyrene-deoxyguanosine adducts by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry |
| |
Authors: | Qiao Zhuanhong Udeochu Uche Jimerson Toiya Fletcher Melissa Bakare Oladapo Hosten Charles M |
| |
Affiliation: | Department of Chemistry, Howard University, Washington, DC 20059, USA. |
| |
Abstract: | A method for the detection of BPDE-d guanosine adducts using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) is described and illustrated. The results indicate that MALDI is capable of detecting two other DNA benzopyrene adducts, which are trace products formed during the synthesis of BPDE-d guanosine. This MALDI-TOFMS method offers the potential for the detection of DNA adducts in human tissue using very limited sample purification and preparation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|