Influence of various factors on the chromatographic behavior of cytostatic antibiotics of rubomicin derivatives in micellar liquid chromatography |
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| Authors: | A. U. Kulikov L. P. Loginova L. V. Samokhina |
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| Affiliation: | (1) Laboratory of Pharmacopoeial Analysis, Scientific and Expert Pharmacopoeial Centre, Astronomicheskaya Street 33, 61085 Kharkov, Ukraine;(2) Department of Chemical Metrology, V.N. Karazin Kharkov National University, Svoboda square, 4, 61077 Kharkov, Ukraine |
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| Abstract: | Summary Micellar liquid chromatography has been adopted for separation of cytostatic antibiotics of rubomicin derivatives. The influence of the kind of organic modifier (normal and iso-alcohols) and its concentration, sodium dodecyl sulfate micelle concentration and column temperature on the chromatographic characteristics of rubomicin derivatives have been investigated. 1-pentanol and iso-propanol were shown to be the most suitable for providing optimum selectivity, good tailing factor and column efficiency with minimum reagent consumption. |
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| Keywords: | Column liquid chromatography Micellar chromatography Sodium dodecy sulfate Cytostatic antibiotics of rubomicin derivatives |
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