Disruption of spinal cord white matter and sciatic nerve geometry inhibits axonal growth in vitro in the absence of glial scarring |
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Authors: | David B Pettigrew Kristina P Shockley Keith A Crutcher |
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Institution: | (1) Department of Neurosurgery, University of Cincinnati College of Medicine, 45267-0515 Cincinnati, Ohio, U.S.A;(2) Dept. of Neurobiology and Anatomy, University of Texas-Houston Health Science Center, P.O. Box 20708, Houston, Texas, U.S.A |
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Abstract: | Background Axons within the mature mammalian central nervous system fail to regenerate following injury, usually resulting in long-lasting motor and sensory deficits. Studies involving transplantation of adult neurons into white matter implicate glial scar-associated factors in regeneration failure. However, these studies cannot distinguish between the effects of these factors and disruption of the spatial organization of cells and molecular factors (disrupted geometry). Since white matter can support or inhibit neurite growth depending on the geometry of the fiber tract, the present study sought to determine whether disrupted geometry is sufficient to inhibit neurite growth. |
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