| 2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸的微波合成及生物活性研究 |
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| 引用本文： | 王良成,唐静,魏太保,张有明. 2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸的微波合成及生物活性研究[J]. 有机化学, 2008, 28(2): 343-347 |
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| 作者姓名： | 王良成 唐静 魏太保 张有明 |
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| 作者单位： | 西北师范大学化学化工学院,甘肃省高分子重点实验室,兰州,730070 |
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| 基金项目： | 国家自然科学基金，教育部科学技术研究重点项目，甘肃省中青年科技研究基金 |
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| 摘 要： | 在微波辐射条件下, 芳氧乙酰肼经两步反应制得4-苯基-3-芳氧甲基-1,2,4-三唑-5-硫酮衍生物, 再与氯乙酸反应得到6种尚未见文献报道的2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸衍生物. 目标化合物的结构经IR, 1H NMR和元素分析进行了确证. 生物活性试验结果表明, 该类化合物对双子叶植物油菜具有良好的生物调节活性.
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| 关 键 词： | 2-(3-芳氧甲基-4-苯基-1,2,4-三唑-5-硫基)乙酸 生物活性 微波合成 三唑 |
| 收稿时间： | 2007-06-07 |
| 修稿时间： | 2007-09-10 |
Synthesis and Biological Activity of 2-(3-Phenoxymethyl-4- phenyl-[1,2,4]triazole-5-thio)acetic Acid |
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| WANG Liang-Cheng,TANG Jing,WEI Tai-Bao,ZHANG You-Ming. Synthesis and Biological Activity of 2-(3-Phenoxymethyl-4- phenyl-[1,2,4]triazole-5-thio)acetic Acid[J]. Chinese Journal of Organic Chemistry, 2008, 28(2): 343-347 |
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| Authors: | WANG Liang-Cheng TANG Jing WEI Tai-Bao ZHANG You-Ming |
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| Affiliation: | (Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070) |
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| Abstract: | Six derivatives of 4-phenyl-3-phenoloxymethyl-5-mercapto-1,2,4-triazlyole were synthesized from phenoloxyacetyl hydrazide by two-steps reaction under microwave irradiation, then reacted with 2-chloroacetic acid to give six novel derivatives of 2-(3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio)- acetic acid. All the products were characterized by elemental analysis, FT-IR and 1H NMR spectra. The preliminary biological activity tests showed that all the compounds have obvious regulating activities for the growth of cole. |
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| Keywords: | 2-(3-phenoxymethyl-4-phenyl-[1,2,4]triazole-5-thio)acetic acid biology activity microwave irradiation triazole |
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