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The synthesis of 3-methyl- and 3,4-dimethyltetrahydroisoquinolines by intramolecular hydroamination with n-butyllithium |
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| Authors: | Willem AL van Otterlo Rakhi Pathak Charles B de Koning Manuel A Fernandes |
| Institution: | aMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits, 2050, Johannesburg, South Africa |
| Abstract: | The synthesis of 3-methyltetrahydroisoquinolines and 3,4-dimethyltetrahydroisoquinolines from aromatic aminoalkenes using intramolecular hydroamination reactions, mediated by sub-stoichiometric amounts of n-butyllithium, is described. |
| Keywords: | Tetrahydroisoquinolines Hydroamination n-Butyllithium |
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