| 一步法合成噻唑并[3,2-b](1,2,4)-三唑类衍生物的研究 |
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| 引用本文： | 王德忠,张正强,张莉莉,史海健. 一步法合成噻唑并[3,2-b](1,2,4)-三唑类衍生物的研究[J]. 有机化学, 2009, 29(7): 1133-1137 |
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| 作者姓名： | 王德忠 张正强 张莉莉 史海健 |
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| 作者单位： | 南京工业大学化学化工学院,南京,210009 |
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| 基金项目： | 国家自然科学基金，江苏省高校自然科学基金 |
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| 摘 要： | 以3-芳基-5-巯基-1,2,4-三唑为原料, 在酸性条件下与乙酰丙酮和乙酰乙酸乙酯一步成环, 制备得到12种新的2-芳基-5-取代-6-甲基噻唑并[3,2-b](1,2,4)-三唑类衍生物. 所有化合物结构经IR, 1H NMR, 13C NMR 和MS及元素分析确证.
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| 关 键 词： | 噻唑并三唑 衍生物 酸性条件 |
| 收稿时间： | 2008-06-30 |
| 修稿时间： | 2006-12-26 |
One-Pot Synthesis of Thiazolo[3,2-b](1,2,4)-triazoles |
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| Wang, Dezhong,Zhang, Zhengqiang,Zhang, Lili,Shi, Haijian. One-Pot Synthesis of Thiazolo[3,2-b](1,2,4)-triazoles[J]. Chinese Journal of Organic Chemistry, 2009, 29(7): 1133-1137 |
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| Authors: | Wang Dezhong Zhang Zhengqiang Zhang Lili Shi Haijian |
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| Affiliation: | (College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009) |
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| Abstract: | Twelve novel compounds, 5-(substituted phenyl)-2-substituent-3-methylthiazolo[3,2-b](1,2,4)- triazole derivatives, were synthesized by a one-pot reaction of 3-(substituted phenyl)-4,5-dihydro-1,2,4- triazole-5-thiones with acetylacetone or acetylacetic ester in the presence of acid. The structures of the com-pounds were confirmed by IR, 1H NMR, 13C NMR, MS techniques and elemental analysis. |
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| Keywords: | thiazolo-triazole derivative acidic condition |
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