Microwave-assisted solid acid-catalyzed one-pot synthesis of isobenzofuran-1(3H)-ones |
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Authors: | Shainaz M Landge Martin Berryman Béla Török |
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Institution: | Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd. Boston, MA, USA |
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Abstract: | A new, solid acid-catalyzed microwave-assisted environmentally benign synthesis of isobenzofuran-1(3H)-ones is described. Montmorillonite K-10 appeared to be an excellent catalyst for the condensation and successive lactonization reactions. Reaction of phthalaldehydic acid (2-carboxybenzaldehyde) with methylaryl and cyclic ketones was initiated by microwave irradiation and occurred in one step. The reactions were complete in 10–30 minutes providing excellent yields (90–98%). |
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