A novel three-component reaction of anilines,formaldehyde and dimedone: simple synthesis of spirosubstituted piperidines |
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| Authors: | Nikolas G Kozlov Aliaksei P Kadutskii |
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| Institution: | Laboratory of Organic Catalysis, Institute of Physical Organic Chemistry, The National Academy of Sciences of Belarus, 13 Surganov Street, Minsk 220072, Belarus |
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| Abstract: | A three-component condensation of anilines with dimedone and formaldehyde leads to the formation of 3,5-dispirosubstituted piperidines. This simple reaction can serve as a convenient source of 3,5-disubstituted piperidines as well as polyfunctional 3-spirofused piperidines. |
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