Synthesis of alpha,beta-unsaturated gamma-lactams via asymmetric iridium-catalysed allylic substitution |
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| Authors: | Spiess Stephanie Berthold Carola Weihofen Robert Helmchen Günter |
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| Affiliation: | Organisch-Chemisches Institut der Ruprecht-Karls-Universit?t Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany. |
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| Abstract: | Syntheses of alpha,beta-unsaturated gamma-lactams are described that are based on ring-closing metathesis in combination with enantioselective Ir-catalysed allylic amination using N-Boc-N-(but-2-enoyl)-amine as a pronucleophile. As an example application, the synthesis of a Baclofen analogue is presented. |
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