Generation of asparagine-linked glycan structure databases and their use |
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Authors: | Hui Ying Gao |
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Institution: | aBioPharmaSoft, Boston, Massachusetts, USA |
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Abstract: | Asparagine linked glycans (N-glycans) are important in biological processes. Yet, their structural complexity and lack of
databases hinder progress in glycomics and glycobiology. We present a way for in silico generation of very large N-glycan
structure databases and their use in high throughput composition and primary structure determination of N-glycans attached
to peptides, based on CID (collision induced dissociation) MS/MS (tandem mass spectrometric data). The database and the integrated
search engine is called Glyquest and is available to the glycomics community. |
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