Iron‐Catalyzed Allylic Amination Directly from Allylic Alcohols |
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| Authors: | Balakumar Emayavaramban Moumita Roy Prof. Dr. Basker Sundararaju |
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| Affiliation: | Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India |
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| Abstract: | Allylic amination, directly from alcohols, has been demonstrated without any Lewis acid activators using an efficient and regiospecific molecular iron catalyst. Various amines and alcohols were employed and the reaction proceeded through the oxidation/reduction (redox) pathway. A direct one‐step synthesis of common drugs, such as cinnarizine and nafetifine, was exhibited from cinnamyl alcohol that produced water as side product. |
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| Keywords: | alcohols allylic compounds amination hydrogen borrowing iron |
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