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Photocatalytic/Cu‐Promoted C−H Activations: Visible‐light‐Induced ortho‐Selective Perfluoroalkylation of Benzamides |
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| Authors: | Xiang Chen Prof?Dr Ze Tan Qingwen Gui Liang Hu Jidan Liu Jing Wu Prof Guangwei Wang |
| Institution: | 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China).;2. Department of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin, P. R. China |
| Abstract: | A visible‐light‐induced and copper‐promoted perfluoroalkylation of benzamides was successfully developed under the assistance of an 8‐aminoquinoline directing group. It provides a straightforward method for the synthesis of ortho‐perfluoroalkyl‐substituted benzoic acid derivatives. The reaction employs a cheap organic dye eosin Y as the photoredox catalyst and is run under the irradiation of a 26 W fluorescent LED light bulb. |
| Keywords: | C− H activation chelation-assisted Cu-promoted perfluoroalkylation photocatalysis |