Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors |
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| Authors: | Katherine M. Byrd Chitra Subramanian Jacqueline Sanchez Hashim F. Motiwala Weiya Liu Prof. Mark S. Cohen Prof. Jeffrey Holzbeierlein Prof. Brian S. J. Blagg |
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| Affiliation: | 1. Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS, USA;2. Department of Surgery, University of Michigan, Ann Arbor, MI, USA;3. Department of Urology, The University of Kansas Medical Center, Kansas City, Kansas, USA |
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| Abstract: | Development of heat shock protein 90 (Hsp90) C‐terminal inhibitors has emerged as an exciting strategy for the treatment of cancer. Previous efforts have focused on modifications to the natural products novobiocin and coumermycin. Moreover, variations in both the sugar and amide moieties have been extensively studied, whereas replacements for the coumarin core have received less attention. Herein, 24 cores were synthesized with varying distances and angles between the sugar and amide moieties. Compounds that exhibited good anti‐proliferative activity against multiple cancer cell lines and Hsp90 inhibitory activity, were those that placed the sugar and amide moieties between 7.7 and 12.1 Å apart along with angles of 180°. |
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| Keywords: | antitumor agents C-terminal inhibitors Hsp90 luciferase refolding medicinal chemistry |
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