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Rhodium‐ and Iridium‐Catalyzed Asymmetric Addition of Optically Pure P‐Chiral H‐Phosphinates to Aldehydes Leading to Optically Active α‐Hydroxyphosphinates |
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| Authors: | Qiang Li Dr Tieqiao Chen Prof?Dr Qing Xu Prof?Dr Li‐Biao Han |
| Institution: | 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Hunan, China;2. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang, China;3. National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan |
| Abstract: | Optically active α‐hydroxyphosphinates with both C‐ and P‐stereogenic centers are obtained by rhodium‐ or iridium‐catalyzed substrate‐directed stereoselective addition of the optically pure H‐phosphinates to aldehydes. The reaction most probably proceeds by a transition‐metal‐catalyzed mechanism with hydridometal complexes as key intermediates in the catalytic cycle. |
| Keywords: | aldehydes hydroxyphosphinates iridium catalyst phosphinates rhodium catalyst stereoselective addition |