Diastereoselective Radical Hydroacylation of Alkylidenemalonates with Aliphatic Aldehydes Initiated by Photolysis of Hypervalent Iodine(III) Reagents |
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Authors: | Sermadurai Selvakumar Ryu Sakamoto Prof. Keiji Maruoka |
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Affiliation: | Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, Japan), Fax: (+81)75-753-4041 |
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Abstract: | Diastereoselective radical hydroacylation of chiral alkylidenemalonates with aliphatic aldehydes is realized by the combination of a hypervalent iodine(III) reagent and UV‐light irradiation. The reaction is initiated by the photolysis of hypervalent iodine(III) reagents under mild, metal‐free conditions, and is the first example of diastereoselective addition of acyl radicals to olefins to afford chiral ketones in a highly stereoselective fashion. The obtained optically active ketones are useful chiral synthons, as exemplified by the short formal synthesis of (?)‐methyleneolactocin. |
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Keywords: | hydroacylation hypervalent iodine radical reactions diastereoselectivity photolysis |
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