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Trichloromethylthiolation of N‐Heterocycles: Practical and Completely Regioselective |
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| Authors: | Johannes B Ernst Andreas Rühling Birgit Wibbeling Prof?Dr Frank Glorius |
| Institution: | 1. Organisch-Chemisches Institut, Westf?lische Wilhelms-Universit?t Münster, Münster, Germany;2. http://www.uni‐muenster.de/Chemie.oc/glorius/
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| Abstract: | The first trichloromethylthiolation of a broad range of indoles and pyrroles is reported employing bench‐stable N‐trichloromethylthiosaccharin as reagent. This methodology is highly regioselective, exhibits high functional group tolerance, and provides access to two previously unknown classes of potentially bioactive compounds. |
| Keywords: | bioactive compounds electrophilic substitution heterocycles organic chemistry trichloromethylthiolation |