Transition‐Metal‐Free Coupling of Alkynes with α‐Bromo Carbonyl Compounds: An Efficient Approach towards β,γ‐Alkynoates and Allenoates |
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| Authors: | Wenbo Liu Dr. Zhengwang Chen Dr. Lu Li Dr. Haining Wang Prof. Dr. Chao‐Jun Li |
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| Affiliation: | Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, Montreal, QC, Canada |
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| Abstract: | A direct transition‐metal‐free coupling between alkynes and α‐bromo carbonyl compounds has been developed with ultraviolet (UV) light in aqueous media. This method represents a facile approach to synthetically useful β,γ‐alkynyl esters and amides stereoselectively from two readily available starting materials. As an example of the synthetic application of the products, the alkynyl esters were readily converted into allenoates. |
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| Keywords: | allenoates green chemistry photochemistry synthetic methods water |
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