Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library |
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| Authors: | Dr. Amanda J Welford Dr. John J. Caldwell Dr. Manjuan Liu Meirion Richards Dr. Nathan Brown Dr. Cara Lomas Dr. Graham J. Tizzard Dr. Mateusz B. Pitak Dr. Simon J. Coles Prof. Suzanne A. Eccles Dr. Florence I. Raynaud Prof. Ian Collins |
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| Affiliation: | 1. Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK;2. UK National Crystallography Service, University of Southampton, Southampton, UK |
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| Abstract: | The 2,11‐cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran‐based compounds designed to augment a typical medicinal chemistry library screen. Ring‐closing metathesis, lactonisation and SmI2‐mediated methods were exemplified and applied to the installation of a third ring to mimic the nine‐membered ring of the 2,11‐cembranoids. The library was assessed for aqueous solubility and permeability, with a chemical‐space analysis performed for comparison to the family of cembranoid natural products and a sample set of a screening library. Preliminary investigations in cancer cells showed that the simpler scaffolds could recapitulate the reported anti‐migratory activity of the natural products. |
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| Keywords: | medicinal chemistry medium-ring compounds molecular diversity oxygen heterocycles synthesis design |
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