Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library |
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| Authors: | Dr Amanda J Welford Dr John J Caldwell Dr Manjuan Liu Meirion Richards Dr Nathan Brown Dr Cara Lomas Dr Graham J Tizzard Dr Mateusz B Pitak Dr Simon J Coles Prof Suzanne A Eccles Dr Florence I Raynaud Prof Ian Collins |
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| Institution: | 1. Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK;2. UK National Crystallography Service, University of Southampton, Southampton, UK |
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| Abstract: | The 2,11‐cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran‐based compounds designed to augment a typical medicinal chemistry library screen. Ring‐closing metathesis, lactonisation and SmI2‐mediated methods were exemplified and applied to the installation of a third ring to mimic the nine‐membered ring of the 2,11‐cembranoids. The library was assessed for aqueous solubility and permeability, with a chemical‐space analysis performed for comparison to the family of cembranoid natural products and a sample set of a screening library. Preliminary investigations in cancer cells showed that the simpler scaffolds could recapitulate the reported anti‐migratory activity of the natural products. |
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| Keywords: | medicinal chemistry medium-ring compounds molecular diversity oxygen heterocycles synthesis design |
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