Synthesis of glycyrrhizic acid conjugates containing L-lysine |
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| Authors: | L A Baltina Jr R M Kondratenko L A Baltina O A Plyasunova F Z Galin G A Tolstikov |
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| Institution: | (1) Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, 450054 Ufa, pr. Oktyabrya, 71;(2) Bashkir State Medical University, 450000 Ufa, ul. Lenina, 3;(3) Vector State Scientific Center of Virology and Biotechnology, 633159 Novosibirsk Dist., Kol’tsovo;(4) Novosibirsk Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, 630090 Novosibirsk, pr. Lavrent’eva, 9 |
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| Abstract: | Activated esters and N-hydroxybenzotriazole-N,N′-dicyclohexylcarbodiimide (DCC) or N-hydroxysuccinimide-DCC were used to synthesize conjugates of glycyrrhizic acid (GA) with Nɛ-carbobenzyloxy-L-lysine Lys(Z)-OH] and its esters containing two or three amino components. It was shown that the conjugate of GA 30-methyl ester with
Lys(Z)-OH possessed anti-HIV-1 activity.
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Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 437–441, September–October, 2006. |
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| Keywords: | glycyrrhizic acid L-lysine |
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