CURCUMIN-DERIVED TRANSIENTS: A PULSED LASER AND PULSE RADIOLYSIS STUDY |
| |
| Authors: | A A Gorman I Hamblett V S Srinivasan P D Wood |
| |
| Institution: | Chemistry Department, University of Manchester, Manchester M13 9PL, UK.;Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA |
| |
| Abstract: | Abstract In this paper we report a time-resolved investigation of transients derived from curcumin, which may be intimately involved in the processes leading to its biological activity. Fluorescence and triplet quantum yields are respectively 0.06 and 0.11. The high percentage of internal conversion is proposed to proceed via H-transfer within the thermodynamically favored enol structure of what is formally a 1,3-diketone. The triplet energy (191 ± 2 kJ mol−1), natural lifetime (1.5 μs) and self-quenching rate constant (5.0 × 108 L mol−1 s−1) have been determined. Oxygen quenching of the triplet leads to the production of singlet oxygen with unit efficiency. Curcumin quenches the latter species very inefficiently (2.5 × 105 L mob−1 s−1). The curcumin radical has been produced via three mechanistically distinct methods. This species is unreactive toward oxygen but is repaired by vitamins C and E and anthralin. |
| |
| Keywords: | |
|
|
