A study on dose response of NIPAM-based dosimeter used in radiotherapy |
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| Authors: | B T Hsieh Y J Chang R P Han J Wu L L Hsieh and C J Chang |
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| Institution: | (1) Institute of Radiological Science, Central Taiwan University of Science and Technology, No. 666, Buzih Rd., Beitun District, Taichung City, 40601, Taiwan, ROC;(2) Department of Management Information Systems, Central Taiwan University of Science and Technology, No. 666, Buzih Rd., Beitun District, Taichung City, 40601, Taiwan, ROC;(3) Institute of Biomedical Engineering and Material Science, Central Taiwan University of Science and Technology, No. 666, Buzih Rd., Beitun District, Taichung City, 40601, Taiwan, ROC;(4) Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, No. 666, Buzih Rd., Beitun District, Taichung City, 40601, Taiwan, ROC; |
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| Abstract: | The newly manufactured N-isopropylacrylamide (NIPAM) polymer gel is composed of four components, i.e., gelatin, monomer (NIPAM), crosslinker (N,N’-methylenebisacrylamide, Bis), and antioxidant (tetrakis hydroxymethyl phosphonium chloride, THPC). In this study, we investigated
the effects of gel composition on the dose response of NIPAM polymer gel. A statistical experiment to analyze the contribution
of each composition to the linearity and sensitivity of NIPAM gel was performed. Results indicate that the amount of gelatin,
NIPAM (15.17%), Bis, and THPC have dominant effects on the sensitivity of the gel, with contributions of 59.73, 15.17, 10.64,
and 14.45%, respectively. The amount of gelatin and Bis mainly affected the linearity of the gel, with contributions of 44.70
and 50.99%, respectively. The linearity of most compositions of the gel was greater than 0.99 when (%C)/(%T) was lower than 8.0. Optimal (%C)/(%T) for higher sensitivity should be in the range of 4−9. The temporal stability experiment showed that the dose response curve
attained stability at about 5 h after irradiation and persisted up to 3 months. |
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