Enhanced relaxation of nanoparticle-bound supercoiled DNA in X-ray radiation |
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| Authors: | Foley Erika A Carter Joshua D Shan Fang Guo Ting |
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| Institution: | Chemistry Department, University of California, Davis, 95616, USA. |
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| Abstract: | A therapeutic methodology was developed based on the large X-ray absorption cross-section of gold nanoparticles at high photon energies (>81 keV). Experimental results showed that the amounts of the relaxed circular supercoiled DNA (scDNA) for gold nanoparticle-bound scDNA were more than doubled compared to that for free scDNA under otherwise identical radiation conditions. |
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