A new environment-sensitive fluorescent amino acid for Fmoc-based solid phase peptide synthesis |
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| Authors: | Eugenio Vazquez M Rothman Deborah M Imperiali Barbara |
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| Institution: | Departments of Chemistry and Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. |
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| Abstract: | A new 4-(N,N-dimethylamino) phthalimide-based environment-sensitive fluorescent building block for solid phase peptide synthesis, has been synthesized and incorporated into peptides. Peptides incorporating this residue show great potential for biological applications in sensing protein/protein interactions. |
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