Synthesis of a variety of optically active hydroxylated heterocyclic compounds using epoxide hydrolase technology |
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Authors: | Daniel P Pienaar |
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Institution: | Oxyrane UK Ltd, 10 Pencroft Way, Greenheys House, Manchester Science Park, Manchester, M15 6JJ, United Kingdom |
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Abstract: | Novel epoxide hydrolases in Yarrowia lipolytica have been shown to hydrolyse a variety of functionalised epoxides with good to excellent stereoselectivity and at high volumetric productivities. Individual biotransformation products have been converted into optically active (R)-(tetrahydrofuran-2-yl)methanol (6), (S)-N-benzyl-3-hydroxypyrrolidine (7), (S)-3-hydroxytetrahydrothiophene (8), (S)-N-benzyl-3-acetoxypiperidine (10), (S)-3-hydroxytetrahydrofuran (16) and (R)-(S)-N-benzylpyrrolidin-2-yl](phenyl)methanol (20). |
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