Cyclization-oxidation of 1,6-enyne derivatived from Baylis-Hillman adducts via Pd(II)/Pd(IV)-catalyzed reactions: stereoselective synthesis of multi-substituted bicyclo[3.1.0] hexanes and insight into reaction pathways |
| |
| Authors: | Hui Liu |
| |
| Affiliation: | Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People’s Republic of China |
| |
| Abstract: | Cyclization-oxidation of Baylis-Hillman adducts provides a convenient method to stereoselectively synthesize variety of multi-substituted bicyclo[3.1.0] ring systems via Pd(II)/Pd(IV)-catalyzed reactions. We also disclose that C-Pd(IV) intermediate can undergo reductive elimination through SN2-type attack by the latent nucleophile of vinyl acetate to afford Csp3-Csp3 bond formation with inversion of configuration at the Pd(IV)-bounded carbon. |
| |
| Keywords: | Baylis-Hillman adduct Bicyclo[3.1.0] SN2-type reductive elimination C-C bond formation Cyclization-oxidation |
| 本文献已被 ScienceDirect 等数据库收录！ |
