Access to chiral tertiary amines via the iridium-catalyzed asymmetric hydrogenation of enamines |
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| Authors: | Pradeep Cheruku |
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| Institution: | Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, S751-23 Uppsala, Sweden |
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| Abstract: | The asymmetric hydrogenation of N,N-dialkyl and N-alkyl-N-aryl enamines to chiral tertiary amines was studied. All the N,P-ligated iridium complexes investigated were active catalysts for the reaction, but only those with bicycle-supported oxazoline-phosphine ligands gave reasonable stereoinduction. The best catalyst produced a range of chiral tertiary amines in up to 87% ee. |
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| Keywords: | Asymmetric catalysis Hydrogenation Enamines Chiral tertiary amines |
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