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A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines |
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| Authors: | Monica Sanna Weng C Chan |
| Institution: | a School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK b Merck Chemicals Ltd., Padge Road, Nottingham NG9 2JR, UK |
| Abstract: | The efficient removal of primary and secondary amines from organic solutions using a macroporous polymer-supported anhydride is described. The sequestering of primary amines by the anhydride via polymer-bound amide formation is completed within 2-4 h at room temperature. Secondary amines require typically 4 h for complete sequestration. |
| Keywords: | Polymer-supported reagents Poly(methacrylic anhydride) Amines Electrophilic scavenger Parallel synthesis |
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