Highly efficient three-component (aldehyde-alkyne-amine) coupling reactions catalyzed by a reusable PS-supported NHC-Ag(I) under solvent-free reaction conditions |
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| Authors: | Pinhua Li Yicheng Zhang |
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| Affiliation: | a Department of Chemistry, Huaibei Coal Teachers College, Huaibei, Anhui 235000, PR China
b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China |
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| Abstract: | The development of a highly efficient, polystyrene-supported NHC-Ag(I) catalyst for the three-component coupling reactions of aldehydes, alkynes, and amines (A3-coupling) was described. In the presence of PS-NHC-Ag(I) (2 mol %), the A3-reactions were carried out at room temperature under solvent-free reaction conditions and the corresponding propargylamines were generated in good to excellent yields. Furthermore, the catalyst could be reused at least 12 times without a significant loss of its catalytic activity. |
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| Keywords: | Three-component coupling reactions Aldehyde-alkyne-amine Propargylamines PS-supported NHC boldFont" >-Ag(I) Solvent-free |
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