Synthesis of indolizidines from dialkylated isocyanides: a novel radical cyclisation/N-alkylation/ring closing metathesis approach |
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| Authors: | Massimiliano Lamberto Jeremy D. Kilburn |
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| Affiliation: | a School of Chemistry, University of Southampton, SO17 1BJ, Southampton, UK
b Department of Chemistry, Medical technology and Physics, Monmouth University, West Long Branch, NJ 07764, USA |
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| Abstract: | Two dialkylated isocyanides were first synthesised from simple starting materials and then used as building blocks for the synthesis of indolizidines via a novel radical cyclisation/N-alkylation/ring closing metathesis strategy. Several functionalised indolizidines were accessed in good to excellent yields. |
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