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A convenient transformation of α-alkylserines into α-halogenomethyl-α-alkylglycines |
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| Authors: | Adam Kudaj |
| Institution: | Institute of Organic Chemistry, Technical University, 90-924 ?ód?, ?eromskiego 116, Poland |
| Abstract: | An efficient and facile synthesis of N-Boc-α-chloromethyl- and α-bromomethyl-α-alkylglycines is reported that involves cyclization of N-Boc-α-alkylserines to the corresponding β-lactones under Mitsunobu reaction conditions, followed by ring opening with anhydrous MgCl2 or MgBr2. |
| Keywords: | N-Boc-α-chloromethyl-α-alkylglycines N-Boc-α-bromomethyl-α-alkylglycines N-Boc-α-alkylserine β-lactones α α-Disubstituted glycines Mitsunobu reaction |
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