|
|||||
|
|
Topsentiasterol sulfates with novel iodinated and chlorinated side chains from the marine sponge Topsentia sp. |
|
| Authors: | Alla G Guzii Vladimir A Denisenko Pavel S Dmitrenok Yuliya V Burtseva Vladimir B Krasokhin Valentin A Stonik |
| Institution: | Pacific Institute of Bioorganic Chemistry, The Far-East Branch of the Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia |
| Abstract: | Three new marine polar steroids, the first chlorine-containing steroid sulfate (1), topsentiasterol sulfate F (2) and the first natural iodinated steroid (3) have been isolated from the marine sponge Topsentia sp. The structures of 1-3 were elucidated using NMR and HRESIMS as well as by chemical correlation of 1 with previously known topsentiasterol sulfate D. Compound 1 proved to be an effective inhibitor of endo-1,3-β-d-glucanase from the marine mollusc Spisula sachalinensis. |
| Keywords: | Polyhydroxysteroid trisulfates Chlorofuran Iodofuran Marine sponge Topsentia endo-1 d-Glucanase" target="_blank">3-β-d-Glucanase 1D and 2D NMR HRESIMS |
| 本文献已被 ScienceDirect 等数据库收录！ | |