A safe, convenient and efficient method for the preparation of heterocyclic N-oxides using urea·hydrogen peroxide |
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| Authors: | Dawen Rong,Ramó n Sá nchez Rubio,Richard T. Wheelhouse |
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| Affiliation: | a School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
b Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain |
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| Abstract: | A novel, convenient, and high-yielding method has been developed for the preparation of heterocyclic N-oxides. The reaction uses the urea·hydrogen peroxide addition complex as a peroxide source for the in situ generation of trifluoroperacetic acid. The advantages of this method are easy handling of a stable, solid oxidant; high yields and simple removal of excess reagents and by-products. |
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| Keywords: | N-Oxide Urea· hydrogen peroxide Trifluoroperacetic acid Pyrimidine Pyridine Quinoline |
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