a Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, IA 52242, United States b Department of Chemistry, X-ray Diffraction Laboratory, The University of Iowa, Iowa City, IA 52242, United States
Abstract:
The bromohydrin reaction in Grieco’s bicyclic lactone 1 was reinvestigated. Two regioisomeric bromohydrins were obtained (2 and 8), and their configurations were unambiguously determined by X-ray diffraction analyses.