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A total synthesis of (+)-isolaurepan |
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| Authors: | Divya Tripathi |
| Institution: | Organic Chemistry Division, National Chemical Laboratory, Pune 411 008, India |
| Abstract: | A versatile and efficient method for the enantioselective synthesis of 2,7-cis-disubstituted oxepane 1c, (+)-isolaurepan, using oxidative resolution of a secondary alcohol and highly diastereoselective Et3SiH/TMSOTf-promoted reductive cyclization of a hydroxy ketone is described. |
| Keywords: | Oxidative resolution of secondary alcohols Cis-selective cyclization Cyclic ethers Oxepanes Isolaurepan |
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