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tert-Butyl isocyanide revisited as a convertible reagent in the Groebke-Blackburn reaction |
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| Authors: | Mikhail Krasavin Sergey Tsirulnikov Yuri Sandulenko |
| Institution: | a Chemical Diversity Research Institute, 2a Rabochaya Street, Moscow Region, Khimki 141400, Russia b Department of Organic and Biological Chemistry, L. N. Tolstoy State Pedagogical University, 125 Lenin Avenue, Tula 300026, Russia |
| Abstract: | tert-Butyl isocyanide can serve as the convertible reagent in Groebke-Blackburn multi-component reactions. The effective removal of the tert-butyl group from the resulting imidazo1,2-a]azines and -azoles is achieved on a gram scale in two steps without chromatographic purification. |
| Keywords: | Groebke-Blackburn multi-component reaction Convertible isocyanide tert-Butyl isocyanide Combinatorial chemistry |
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