Efficient access to 2,5-substituted tetrahydrofurans via a one-pot cyclization of di- and triepoxides |
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Authors: | Gordon J. Florence Romain Cadou |
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Affiliation: | EaStCHEM and Centre for Biomolecular Sciences, School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK |
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Abstract: | The one-pot addition and cyclization of 1,5-diepoxyhexane with a range of organolithium species provides efficient access to 2,5-substituted tetrahydrofurans (THFs), common structural motifs found in a range of natural products and pharmaceutical ingredients. Extension of this reaction to triepoxides has also been demonstrated to access adjacently linked bis-THF motifs in a single step. |
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