Copper-free Sonogashira coupling in amine-water solvent mixtures |
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| Authors: | Anna Komá romi |
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| Affiliation: | Department of Organic Chemistry, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest, Hungary |
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| Abstract: | Extensive study of different amine-water solvent mixtures was carried out for copper free Sonogashira coupling of aryl iodides. The influence of the palladium sources, ligands, amine-water ratio and further additives was also evaluated. Application of sec-butylamine-water mixture proved to be an excellent medium for rapid and efficient coupling of aryl-iodides at ambient temperature in the presence of PdCl2(PPh3)2 as catalyst. |
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| Keywords: | Cross-coupling Acetylenes Sonogashira reaction Palladium |
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