| 单链DNA在受限环境中伸展的Monte Carlo模拟 |
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| 作者单位： | 中国科学技术大学化学与材料科学学院,合肥,230026;合肥工业大学机械与汽车工程学院,合肥,230009 |
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| 摘 要： |
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| 关 键 词： | Monte Carlo模拟 键长涨落算法 DNA分子 受限程度 高分子链构象 |
Monte Carlo Simulation on Stretching of Single DNA Molecules in Confined Environments |
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| Authors: | Zhang Huming Xie Yongjun He Xiujuan Shi Qinwei Zhu Pingping Yang Haiyang |
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| Abstract: | Stretching and relaxation of a single DNA molecule tethered in a specially designed thin slit were studied using Monte Carlo simulation combined with bond fluctuation method. It was found that the extension and relaxation of the single DNA molecule are greatly affected by the confined environment. If the extent of the confined environment is increased by decreasing the distance between the two planar surfaces of the slit, the extension of the single DNA molecule increases, due to the screening of the hydrodynamic interaction of DNA segments by the planar surfaces of the slit. The relaxation of the single DNA molecule in different confined environments verifies this assumption completely. The correlation between the end-to-end separation and flow velocity obtained by Monte Carlo simulation is in good agreement with either the experimental results or theoretical consideration reported previously. |
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| Keywords: | Monte Carlo simulation Bond-fluctuation method DNA molecules Degree of confinement Polymer conformation |
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